KMID : 0383820110700030257
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Tuberculosis and Respiratory Diseases 2011 Volume.70 No. 3 p.257 ~ p.260
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A Case of Pulmonary Fibrosis with Microscopic Polyangiitis
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Jeong Jae-Ho
Kang Sung-Hee Park Se-Jung Kim Dal-Yong Kim Woo-Sung Kim Dong-Soon Song Jin-Woo
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Abstract
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A 65-year-old woman was admitted due to poor oral intake and a dry cough over the previous 3 months. The physical examination was remarkable for bibasilar crackles, and plain chest radiography showed reticulation in both lower lung fields. A pulmonary function test demonstrated a restrictive pattern with a reduced diffusing capacity of the lung for carbon monoxide. High resolution computed tomography showed reticulation and honey-combing in both peripheral lung zones, which was consistent with usual interstitial pneumonia pattern. Her skin showed livedo reticularis. The erythrocyte sedimentation rate and C-reactive protein level were elevated, and hematuria was noted on urinary analysis. A serologic test for auto-antibodies showed seropositivity for Myeloperoxidase-Anti-neutrophil cytoplasmic antibody (MPO-ANCA). A kidney biopsy was performed and showed focal segmental glomerulosclerosis. She was diagnosed as having pulmonary fibrosis with microscopic polyangiitis (MPA) and treated with high dose steroids. Here we report a case of pulmonary fibrosis coexistent with microscopic polyangiitis.
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KEYWORD
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Pulmonary Fibrosis, Microscopic Polyangiitis, Antibodies, Antineutrophil Cytoplasmic
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